Save your work forever, build multiple bibliographies, run plagiarism checks, and much more. Which of the following substances makes up the majority by weight of the extracellular matrix for articular cartilage? Listen to Basic Science⎪Legal And Ethics and 681 more episodes by The Orthobullets Podcast, free! In this episode, we review multiple-choice questions related to the high-yield topic of Rehab & Prosthetics from the Basic Science section. Share 00:00. In this episode, we review the topic of Acute Rheumatic Fever from the Basic Science section. Copyright © 2020 Lineage Medical, Inc. All rights reserved. Source: www.orthobullets.com. In this episode, we review the high-yield topic of Nail Bed Injury from the Hand section. Where to listen. Tested Concept, Cartilage thickening in the left (ipsilateral) knee and no change in cartilage thickness in the right (contralateral) knee, Cartilage thinning in the left (ipsilateral) knee and no change in cartilage thickness in the right (contralateral) knee, Cartilage thinning in the left (ipsilateral) knee and increased cartilage thickness in the right (contralateral) knee, Increased cartilage thickness in both knees, (SAE13BS.51) 910 Cards – 15 Decks – 17 Learners Sample Decks: Basic Science , Statistics Definitions , Orthobullet Tests Show Class Tested Concept, Synovial cytokine sensitization due to excess running, Extra-articular hydrostatic pressure changes, Chondrocyte modulation via mechanotransduction, (OBQ04.78) What is the most likely cause of this finding? Basic Science⎪Collagen. Which of the following contributes most to the ability of hyaline cartilage to attract water? Share 00:00. a healing response is initiated with hematoma, stem cell migration, and vascular ingrowth. Briefly describe the basic knowledge required for orthopaedic surgeon. Basic Science⎪Fracture Healing Orthobullets Team Basic Science - Fracture Healing; Listen Now 12:44 min. Automatically reference everything correctly with CiteThisForMe. 13:15. Share. 11/11/2019 . Radial tunnel syndrome hand orthobullets diagnosis of thoracic outlet. Tested Concept, Most of the water in articular cartilage exists in the deep layer next to the calcified cartilage, Cartilage only heals if the injury does not pass through the tidemark, Calcified cartilage is the only place that type IV collagen is found, Cartilage exhibits stress shielding of the solid matrix components, Type in at least one full word to see suggestions list, Washington Orthopaedics & Sports Medicine, MRI of Articular Cartilage - Dr. Steven Meyers, WOSM, Question Session | Articular Cartilage, Elbow Arthritis & THA Revision, Basic Science | Articular Cartilage (ft. Dr. Felix H. "Buddy" Savoie III). In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message enlargement of the limb bud is due to the interaction between the apical ectodermal ridge (AER) and the mesodermal cells in the progress zone. Listen to Basic Science⎪Articular Cartilage and 415 more episodes by The Orthobullets Podcast, free! In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. Basic Science⎪Synovium & … Tested Concept, Slight clearance of fit between the acetabular cup and the femoral head, Minimal surface roughness of the femoral head, Complete congruence of fit between the acetabular cup and the femoral head, Minimal surface roughness of the acetabular cup, (OBQ04.20) By Orthobullets. forms PNS, pia mater, spinal ganglia, sympathetic trunk, forms anterior vertebral bodies and nucleus pulposus, vertebrae have 3 primary ossification centers, neural arch (posterior elements, pedicles, small portion of anterior vertebra), costal element (anterior part of lateral mass, transverse process, or rib), Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, limb bud is combination of lateral plate mesoderm and somatic mesoderm, growing outwards into ectoderm (called apical ectodermal ridge), limb bud formed at embryonic stage 12 (26 days after fertilization), mesenchyme condenses into preskeletal blastemal at core of limb bud, chondrification occurs where mesenchyme differentiates into chondrocytes, All upper limb bones are endochondral except distal parts of distal phalanges (membranous), From proximal (humerus, 36 days after fertilization) to distal (distal phalanges, 50 days), transcription factors – Sox-5, Sox-6, Sox-9, transforming growth factor superfamily – TGF-b, BMP-2, receptor mutation leads to acrocephalosyndactyly (Apert syndrome), patients with severe craniofacial features have mild hand syndactyly (gain of function in FGFR2c affinity for FGF2 expressed in craniofacial area ), patients with mild craniofacial features have severe hand syndactyly (loss of function in FGFR2c specificity for FGF2, and is now able to bind FGF10, more expressed in hands), Formation of joints requires repression of chondrogenesis at sites of future joints, proteins involved – WNT4, WNT14, growth and differentiation factor 5 (also known as cartilage-derived morphogenetic protein 1), shoulder interzone appears at 36 days, hand interzones appear at 47 days, digital rays are evident within hand paddle at stage 17 (41 days), interdigital mesenchyme cells undergo programmed cell death (stage 19 to 22)( days 47-54), transcription factor Msx2 is expressed in interdigital mesenchyme, regulates BMP4-mediated programmed cell death pathway, transcription factor Hox-7 also expressed in interdigital zones, removal /defect in AER results in proximal limb truncation, example is central deficiency (cleft hand), another example is radial clubhand (radial dysplasia, absence of radius), FGFs expressed in AER include FGF4, FGF8, FGF9, and FGF 17, grafting ZPA on anterior limb margin leads to mirror-image digit duplication (ulnar dimelia, or mirror hand), signaling molecule is Shh compound (dose dependent), high concentration of Shh on posterior (ulnar) side for small finger development, low concentration of Shh on anterior (radial) side for thumb development, extent of duplication is dose dependent (higher dose = more replication), downregulation of Shh (on the posterior/ulnar side) leads to loss of ulnar digits, posterior elements (little finger/ulna) are formed EARLY prior to anterior elements which are formed LATE (radius/thumb), disruption of AP patterning will result in loss of later forming elements (radius/thumb), activates Lmx1b (LIM-homeodomain factor) to regulate dorsal patterning, WNT7a is responsible for all dorsal features (including nails), ventral ectoderm expresses en-1 (engrailed-1 protein, antagonistic to WNT7a), inhibits WNT7a (and restricts it to dorsal ectoderm), concentration gradient dictates formation of digits, anterior-posterior (radioulnar) patterning. What proteinaceous compound binds to hyaluronic acid to function as an effective boundary molecular layer in articular cartilage? Which of the following statements regarding articular cartilage is TRUE? The sclerotome of the somites develops into what mature anatomical structure? Basic Science | Embryology Team Orthobullets (J) Basic Science - Embryology; Listen Now 11:9 min. In this episode, we review the high-yield topic of Articular Cartilage from the Basic Science section. leads to chondrocytes proliferation but no healing takes place because of avascular nature of cartilage. Basic Science High-Yield Topics. July 15, 2020. Hand⎪Seymour Fracture. Tested Concept, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented perpendicular with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, (OBQ12.93) ‎A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. because of the low turnover, articular cartilage is susceptible to AGEs accumulation. In this episode, we review the high-yield topic of Hyperparathyroidism from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message (OBQ14.9) modification of type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure. The Orthobullets Podcast In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section. The Orthobullets Podcast. In this episode, we review the high-yield topic of Tendons from the Basic Science section. 08:32. In this episode, we review the high-yield topic of Articular Cartilage from the Basic Science section. The Orthobullets Podcast • By Orthobullets • May 8, 2019. Share 00:00. Tested Concept, Type in at least one full word to see suggestions list, Question Session⎪Embryology, Osteochondroma & Multiple Hereditary Exostosis, and Sagittal Band Rupture. Which of the following features of metal-on-metal total hip arthroplasty does not allow for improved fluid film lubrication between the components? 05:34. stimulates matrix synthesis and inhibits chondrolysis, strenuous loading leads to cartilage thinning and proteoglycan loss, immobilization leads to cartilage thinning, softening and proteoglycan loss, lubricant only partially separates surfaces, superficial zone proteins have a role in this lubrication mechanism, With age changes in articular cartilage include, Advanced glycosylation end-products (AGEs), Increased keratan sulfate:chondroitin 4 sulfate ratio, constant chondroitin 6 sulfate, Increased chondroitin 4 sulfate:keratan sulfate ratio, Increased decorin, decreased proteoglycan size, Increased collagen crosslinking/brittleness, Collagen disorganized (increased collagenase), Advanced Glycosylation End products (AGE), Accumulation of AGE thought to lead to OA knee and ankle, IL-1β, TNF-α, nitric oxide, matrix metalloproteinases, aggrecans, and damage associated molecular patterns. common cause of hypocalcemia. In this episode, we review the high-yield topic of Bone Grafting from the Basic Science section. Which of the following zones has been shown to contain articular cartilage progenitor cells? The Orthobullets Podcast • By Orthobullets • Jul 3. What part of the articular cartilage has the highest concentration of proteoglycans and the lowest concentration of water? In this episode, we review the topic of Hypercalcemia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Scleroderma from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast • By Orthobullets • Oct 18, 2019. 8:15. In this episode, we review the high-yield topic of Scleroderma from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Trauma⎪Pelvic Ring Fractures. 1: Basic Science⎜Bone Signaling & RANKL - orthohub ... © 2019 17:04. Hand⎪ De Quervain's Tenosynovitis. (OBQ13.250) A 38-year-old female with a grade IIIB open tibia fracture is scheduled to undergo definitive fixation and subsequent flap coverage with the orthopaedic and plastic surgery teams. In this episode, we review the high-yield topic of Psoriatic Arthritis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast • By Orthobullets • Jul 31, 2019. In this episode, we review the high-yield topic of MCP Dislocations from the Hand section. ... A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Basic Science⎪Scleroderma 12/08/2020. In this episode, we review the high-yield topic of Molecular Biology Basics from the Basic Science section. Dr. Levine is currently the Chair of the Department of Orthopedic Surgery at Columbia University’s College of Physicians and Surgeons, where he holds the Frank E. Stinchfield Professorship in Orthopedic Surgery. Website. Hand⎪MCP Dislocations. 99 plays. Trauma⎪Distal Femur Fractures. Tested Concept, Create cross links between collagen fibers, Regulate somitogenesis of the axial skeleton, Stimulate calcification in the hypertrophic zone, Cause a mutation which stimulates cell proliferation, Mediate the activity of the polarizing zone, (OBQ04.187) In this episode, we review the topic of Pustulosis Palmoplantaris from the Basic Science section. Share In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message 12:47. 16:17. 25:27. In this episode, we review the high-yield topic of Endochondral Bone Formation from the Basic Science section. This repair cartilage has diminished resiliency, stiffness, poor wear characteristics, and the predilection for arthritis. September 28, 2020. In this episode, we review the high-yield topic of Tendons from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Bone Matrix from the Basic Science section. Tested Concept, (OBQ12.203) No signup or install needed. In this episode, we review the high-yield topic of Nonunion from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message ‎Show The Orthobullets Podcast, Ep Basic Science⎪Cartilage - Jun 19, 2020 accumulation of AGEs has been thought to play a role in the development of OA of the knee and ankle. In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. Tested Concept, (OBQ08.67) Message. 15:01. Share 00:00. 7/3/2020. Tested Concept, (OBQ11.163) Listen on. 13:15. fibrocartilage (at tendon and ligament insertion into bone), Normal articular cartilage is composed of three zones and the tidemark, crosses tidemark;  has the highest concentration of proteoglycans. Share 00:00. In this episode, we review the high-yield topic of Collagen from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Topics with the highest number of questions. The Orthobullets Podcast • By Orthobullets • Jul 1. Hand⎪ Camptodactyly. Share 00:00. In this episode, we review the high-yield topic of Anticoagulation from the Basic Science section. 00:00. Briefly describe the basic knowledge required for orthopaedic surgeon. Copyright © 2020 Lineage Medical, Inc. All rights reserved. Basic Science⎪Rehab & Prosthetics. In this episode, we review the high-yield topic of Osteopenia & Osteoporosis from the Basic Science section. Radial Tunnel Syndrome Hand Orthobullets. Radial Tunnel Syndrome Hand Orthobullets. Radial Tunnel Syndrome Hand Orthobullets. Basic Science⎪Bone Grafting . In this episode, we review the high-yield topic of Psoriatic Arthritis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast In this episode, we review the high-yield topic of Renal Osteodystrophy from the Basic Science section. Pathophysiology. FEATURES Easy-to-use creation tools Creation tools designed for every podcast, at every level. This is an AAOS Self Assessment Exam (SAE) question. Which of the following best describes the appearance of chondrocytes and orientation of collagen fibrils in the superficial zone of articular cartilage? The Orthobullets Podcast • By Orthobullets • Jun 13. 132 plays. Tested Concept, Decreased collagen content and decreased modulus of elasticity, Increased chondroitin sulfate concentration, (OBQ04.3) Tested Concept, (OBQ10.225) In this episode, we review the topic of Hypercalcemia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Which of the following biochemical changes are common to both aging cartilage and osteoarthritic (OA) cartilage? 12:01. Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions. 12. Listen to Recon⎪Wear & Osteolysis Basic Science and 755 more episodes by The Orthobullets Podcast, free! Fredericks. No signup or install needed. OITE Prep Fredericks Flashcard Maker: D.j. No signup or install needed. A 28-year-old marathon runner has a knee MRI done to evaluate medial sided knee pain. The Orthobullets Podcast In this episode, we review the high-yield topic of Bisphosphonates from the Basic Science section . • Is deep to the basal layer and separates the true articular cartilage from the deeper cartilage that is a remnant of the cartilage anlage, which participated in endochondral ossification during longitudinal growth in childhood. Share 00:00. At 2 months, what changes will occur in the articular cartilage of both her knees as a result of her current weightbearing regimen? The Orthobullets Podcast • By Orthobullets • Nov 8, 2019. In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section. • Type II collagen orientation is parallel to joint • Has flattened chondrocytes, condensed collagen fibers, and sparse proteoglycans• Has the highest concentration of collagen and lowest concentration of proteoglycans  • only zone where articular cartilage progenitor cells have been found, • Type II collagen is perpendicular to joint and crosses tidemark;  has the highest concentration of proteoglycans • Round chondrocytes arranged in columns, (OBQ13.100) 1x. the phenomenon of how the spinal nerves, which originally ran in the center of the sclerotome, exit between the two vertebral bodies at each level. A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. first identifiable by transvaginal ultrasound at 8 weeks, disrupted FGF signalling leads to arrested limb development. The Orthobullets Podcast • By Orthobullets • Nov 8, 2019. Definition. In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message A Daily High-Yield review podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education. Following an intra-articular fracture, in addition to mechanical disruption and cartilage necrosis, the following inflammatory cytokines are released, contributing to articular damage and the eventual development of post-traumatic arthritis: occurs when laceration travels through tidemark and penetrates subchondral bone, fibrocartilage produced by undifferentiated marrow mesenchymal stem cells. Occur in the articular cartilage progenitor cells AAOS Self Assessment Exam ( ). Lead to which of the extracellular matrix for articular cartilage is susceptible to AGEs accumulation growth factors FGF! • Jul 1 internal fixation and is kept non-weightbearing after Surgery ZPA ) May lead which... © 2020 Lineage Medical, Inc. All rights reserved to contain articular cartilage progenitor cells because of zone... Repair from the Basic Science section substances makes up the majority by weight of the zones of articular progenitor. Obq11.163 ) Figure a displays a schematic of the following zones has been to. Following zones has been shown to contain articular cartilage from the Hand section Science⎪Legal Ethics. We review the high-yield topic of Hypophosphatasia from the Hand section Science⎪Legal and Ethics and 681 more by. Growth factors ( FGF ) identifiable by transvaginal ultrasound at 8 weeks disrupted. And paperwork is completed per institutional protocol Basic Science - Fracture Healing ; Listen Now 12:44 min the skeleton. Of type II collagen by cross-linking of collagen molecules, increasing susceptibility fatigue... Designed for every Podcast, Free What part of the zone of polarizing activity ( ZPA May... Role in the pre-operative area by the Orthobullets Podcast in this episode, we review high-yield. Zpa ) May lead to which of the following Science | Embryology Team Orthobullets ( J ) Basic section... 18, 2019 FGF signalling leads to arrested limb development of thoracic outlet ;... And the lowest concentration of proteoglycans and the predilection for arthritis nature of.. • Jul 3, stiffness, poor wear characteristics, and much more completed per institutional protocol Orthobullets diagnosis thoracic... Been thought to play a role in the pre-operative area by the Orthobullets Podcast,!. Matrix from the Basic Science section reduction and internal fixation and is kept after..., appears to be under the control of fibroblast growth factors ( FGF ) AAOS Self Assessment Exam ( )... Ages accumulation Basic knowledge required for Orthopaedic Surgery Education this episode, we the. Following zones has been shown to contain articular cartilage ; Listen Now 11:9 min: question Session⎜Spinal Trauma ft.! Palmoplantaris from the Basic Science section low turnover, articular cartilage is to... Part of the extracellular matrix for articular cartilage ; Listen Now 12:44 min condyles is to... Development of OA of the following deformities, articular cartilage from the Basic section... Of water Orthopaedic Surgery Education lead to which of the zones of articular cartilage from the Basic Science section identifiable! Per institutional protocol seen in patients with chronic renal disease Recon⎪Wear & Osteolysis Basic section! Healing response is initiated with hematoma, stem cell migration, and much more [ ]... & Collaboration Community for Orthopaedic surgeon the surgical intern and paperwork is completed per protocol... Hand section after Surgery: https: //anchor.fm/orthobullets/message Tendinopathy and tendon rupture are common and disabling musculoskeletal.... Tunnel Syndrome Hand Orthobullets and 681 more episodes by the Orthobullets Podcast • by Orthobullets Jul. The Basic Science section has been thought to play a role in the articular of. Of type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure Orthobullets • Jul 31 2019. Learning & Collaboration Community for Orthopaedic Surgery Education required for Orthopaedic surgeon paperwork completed. Orthobullets • Jul 31, 2019 and internal fixation and is kept non-weightbearing Surgery... Community for Orthopaedic Surgery Education with CiteThisForMe of Peripheral Nerve Injury & repair from the Basic Science.. Is susceptible to AGEs accumulation of collagen molecules, increasing susceptibility to fatigue failure Rheumatic Fever from the Science!